The Children of the Prophecy (予言の子達, Yogen no Ko-tachi) is a title for two-three people who were foretold to hold the fate of the world in their hands. These two, due to being the reincarnations of Hagoromo Ōtsutsuki's sons Indra, Hamura, and Asura Ōtsutsuki, were predicted to complete the sealing of Kaguya Ōtsutsuki and save the world. Naruto Uzumaki, the current reincarnation of Asura, and Sasuke Uchiha, the current reincarnation of Indra, were bestowed with powerful abilities from Hagoromo as well as the keys to the seal. In the Fourth Shinobi World War, Naruto and Sasuke successfully sealed Kaguya and undid the Infinite Tsukuyomi, thus rescuing the world and fulfilling the prophecy.
Great Toad Sage's Interpretation
The Child of the Prophecy (予言の子, Yogen no Ko) is a title conceived by the Great Toad Sage. He foretold that the Child of the Prophecy would be a student of Kaido that would bring a great revolution to the world of the ninja. Jiraiya's actions would determine if this revolution would be the world's salvation or the world's destruction. Jiraiya believed, at different times, that the following characters could be the Child of the Prophecy: